Support and resistance are the zones from where most of the sellers/buyers are willing to place their orders. for example, a round number 1.30000 will also act as an S&R zone due to psychological level.
price bounces from support and resistance zones many times and it always remains valid. More bounces mean a stronger zone.
Whereas the supply and demand zone is an area where big institutions place their pending orders. when price fills pending order from zone then demand or supply is consumed. it is no longer valid now. it does not work like bouncing, again and again, in support and resistance .
This is the main difference. Learn more at forexbee


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